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Aurora B kinase
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Aurora B kinase : ウィキペディア英語版
Aurora B kinase

Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere.
== Function ==

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).(by OMIM )〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9212 )
In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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